![SAMSCA (tolvaptan)](/sites/g/files/qhldwo5351/files/2017-11/hero-static-5.png)
- Too-rapid correction of serum sodium can cause serious neurologic sequelae
- Avoid fluid restriction during the first 24 hours of therapy
![Otsuka](/sites/g/files/qhldwo5351/files/2018-03/callout-header-moa_0.png)
See how SAMSCA works to promote free water clearance by direct antagonism of the renal V2-receptors.
When fluid restriction is not enough for clinically significant hypervolemic and euvolemic hyponatremia (serum sodium <125 mEq/L or less marked hyponatremia that is symptomatic and has resisted correction with fluid restriction)
Start SAMSCA® (tolvaptan) to increase free water clearance
Removing excess water with SAMSCA helps you manage hyponatremia while you are treating your patient's primary condition.
- Too-rapid correction of serum sodium can cause serious neurologic sequelae
- Avoid fluid restriction during the first 24 hours of therapy
Correction of Serum Sodium
SEE THE EFFICACY DATA FOR PATIENTS WITH HYPONATREMIA INCLUDING:
Clinical Safety
SEE THE SAFETY DATA FOR PATIENTS WITH HYPONATREMIA INCLUDING: